Wynne LeGrow was born Québec, Canada and raised in Vermont and Ohio. His father was a Protestant minister and his mother was a schoolteacher. He received his undergraduate and medical degree from The Ohio State University. After doing an internal medicine residency at the University of Missouri, he completed a nephrology fellowship at the University of Connecticut. While serving two years as an Army doctor at Fort Rucker, Alabama he was promoted to the rank of major.
Dr. LeGrow moved to Emporia Virginia in 1979. He practiced internal medicine and nephrology there until 2008. In 2010 he was the Democratic nominee for the US House of Representatives in Virginia's fourth Congressional District and ran openly as an atheist. His opponent was Republican Congressman Randy Forbes, the founder and chairman of the Congressional Prayer Caucus. Congressman Forbes refused to debate Dr. LeGrow during the campaign. Democrats did not do well in 2010. Although LeGrow lost, he received a higher percentage of the vote than any other Democrat running against an incumbent Republican in the state of Virginia.
After his run for Congress, LeGrow wrote his memoir, Last Leper in the Colony: An Atheist Runs for Congress in the Bible Belt.